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Biotransformations & Microbioreaction Engineering

Dr.-Ing. Katrin Rosenthal Foto von Dr.-Ing. Katrin Rosenthal

Telefon
(+49)231 755-5115

Adresse

Raum G1 6.14

Publikationen

ORCID

Publikationen

2022

  • Siedentop R., Rosenthal K. 
    Industrially Relevant Enzyme Cascades for Drug Synthesis and Their Ecological Assessment
    International Journal of Molecular Science, 2022, 23(7), 3605 DOI
  • Grühn J., Behr A., Eroglu T., Trögel V., Rosenthal K., Kockmann N.
    From Coiled Flow Inverter to Stirred Tank Reactor – Bioprocess Development and Ontology Design
    Chemie Ingenieur Technik, 2022, 94(6), 1-13 DOI
  • Bartsch T., Becker M., Rolf J., Rosenthal K., Lütz S. 
    Biotechnological production of cyclic dinucleotides — Challenges and opportunities
    Biotechnology and Bioengineering, 2021, 119, 677-684  DOI

2021

  • Siedentop R., Claaßen C., Rother D., Lütz S., Rosenthal K.
    Getting the Most Out of Enzyme Cascades: Strategies to Optimize In Vitro Multi-Enzymatic Reactions
    Catalysts, 2021, 11, 1183 DOI
  • Rolf J., Nerke P., Britner A., Krick S., Lütz S., Rosenthal K.
    From Cell-Free Protein Synthesis to Whole-Cell Biotransformation: Screening and Identification of Novel α-Ketoglutarate-Dependent Dioxygenases for Preparative-Scale Synthesis of Hydroxy-L-Lysine
    Catalysts, 2021, 11(9), 1038 DOI
  • Kinner A., Rosenthal K., Lütz S.
    Identification and Expression of New Unspecific Peroxygenases – Recent Advances, Challenges and Opportunities
    Frontiers in Bioengineering and Biotechnology, 2021, 9:705630 DOI
  • Schmitz LM., Hageneier F., Rosenthal K., Busche T., Brandt D., Kalinowski J., Lütz S.
    Recombinant Expression and Characterization of Novel P450s from Actinosynnema mirum
    Bioorganic & Medicinal Chemistry, 2021, 116241 DOI
  • Becker M., Nikel P., Andexer JN., Lütz S., Rosenthal K.
    A Multi-Enzyme Cascade Reaction for the Production of 2'3'-cGAMP
    Biomolecules, 2021, 11(4), 590 DOI
  • Schmitz LM., Kinner A., Althoff K., Rosenthal K., Lütz S.
    Investigation of vitamin D2 and vitamin D3 hydroxylation by Kutzneria albida
    ChemBioChem, 2021, 22, 2266–2274 DOI
  • Becker M., Lütz S., and Rosenthal K.
    Environmental Assessment of Enzyme Production and Purification
    Molecules, 2021, 26(3), 573 DOI
  • Schwarz J., Hubmann G., Rosenthal K., and Lütz S.
    Triaging of Culture Conditions for Enhanced Secondary Metabolite Diversity from Different Bacteria
    Biomolecules, 2021, 11(2), 193 DOI
  • Rosenthal K.
    Is Gender Equality Still an Issue? Gender (Im)balances in STEM
    Chemieingenieurtechnik, 2021, 93(8), 1-4 DOI

2020

  • Rosenthal K., Becker M., Rolf J., Siedentop R., Hillen M., Nett M., and Lütz S. (2020)
    Catalytic promiscuity of cGAS: A facile enzymatic synthesis of 2’‐3’ linked cyclic dinucleotides
    ChemBioChem, 21, 3225-3228 DOI
  • Schwarz J., Rosenthal K., Snajdrova R., Kittelmann M., and Lütz S. (2020)
    The Development of Biocatalysis as a Tool for Drug Discovery
    CHIMIA, 74(5):368-377
  • Rolf J., Julsing M., Rosenthal K., and Lütz S. (2020)
    A Gram-Scale Limonene Production Process with Engineered Escherichia coli
    Molecules, 25(8):1881 DOI
  • Rolf J., Siedentop R., Lütz S., and Rosenthal K. (2020)
    Screening and Identification of Novel cGAS Homologues Using a Combination of In Vitro and In Vivo Protein Synthesis
    International Journal of Molecular Science, 21(1):105 DOI

2019

  • Schmitz LM., Rosenthal K., Lütz S. (2019)
    Recent Advances in Heme Biocatalysis Engineering
    Biotechnology and Bioengineering, 116(12):3469-3475 DOI

  • Schmitz LM., Schäper J., Rosenthal K., Lütz S. (2019)
    Accessing the biocatalytic potential for C-H-activation by targeted genome mining and screening
    ChemCatChem, 11(23) DOI

  • Rolf J., Rosenthal K., and Lütz S. (2019)
    Application of Cell-Free Protein Synthesis for Faster Biocatalyst Development
    Catalysts. 2019; 9(2):190 DOI

2018

  • Rosenthal K. and Lütz S. (2018)
    Recent developments and challenges of biocatalytic processes in the pharmaceutical industry
    Current Opinion in Green and Sustainable Chemistry, 11:58-64 DOI

2017

  • Schmitz L., Rosenthal K., and Lütz S. (2017)
    Enzyme-based electrobiotechnological synthesis
    In: Harnisch F., Holtmann D. (eds) Bioelectrosynthesis. Advances in Biochemical Engineering/Biotechnology, vol 167. Springer, Cham DOI

  • Rosenthal K., Oehling V., Dusny C. and Schmid A. (2017)
    Beyond the bulk: Disclosing the life of single microbial cells
    FEMS Microbiology Reviews, 41(6):751-780 DOI

2015

  • Rosenthal K., Falke F., Frick O., Dusny C. and Schmid A. (2015)
    An inert continuous microreactor for the isolation and analysis of a single microbial cell
    Micromachines, 6(12):1836-1855 DOI

2013

  • Fritzsch F. S. O., Rosenthal K., Kampert A., Howitz S., Dusny C., Blank L. M. and Schmid A. (2013)
    Picoliter nDEP traps enable time-resolved contactless single bacterial cell analysis in controlled microenvironments
    Lab on a Chip, 13(3):397-408 DOI

Vorträge

  • Rosenthal K., Rolf J., Becker M., Siedentop R., Lütz S.
    Towards accelerated bioprocess development: Using cell-free protein synthesis to screen for promising biocatalysts
    6th BioProScale Berlin, 29. - 31. March 2021, online
  • Rosenthal K. (2020) (invited lecture)
    Microbioreactors for Biotransformations and Whole Cell Biocatalysis
    µTAS 2020 (24th International Conference on miniaturized Systems for Chemistry and Life Science), 3. - 4. October 2020, online
  • Rosenthal K., Rolf J., and Lütz S. (2019)
    Cell-free protein synthesis: Accelerating biocatalyst development
    German Conference on Synthetic Biology, 12. - 13. September 2019, Aachen, Germany

  • Rosenthal K., Becker M., Rolf J., and Lütz S. (2018)
    Enzymatic synthesis of cyclic dinucleotides
    Emerging Trends in Natural Product Biotechnology, 20. - 21. September 2018, Dortmund, Germany

  • Rosenthal K., Dusny C. and Schmid A. (2015)
    The next-generation Envirostat: An inert microfluidic bioreactor for the isolation and analysis of a single microbial cell in defined environments
    6th International Conference on Analysis of Microbial Cells at the Single Cell Level, 19-22 July 2015, Retz, Austria

  • Rosenthal K., Dusny C., Oehling V., Frick O. and Schmid A. (2014)
    Analysis of a single-cell: Imprisoned, but feeling well
    5th annual CLIB-graduate cluster retreat, 12. – 14. February 2014, Lünen, Germany

Poster

  • Rosenthal K., Grühn J., Behr A., Eroglu T., Trögel V., Kockmann N.
    Biocatalytic Reaction and Process Development using a Coiled Flow Inverter –From Reactor Concept to Ontology Design (Best poster award)
    13th European Congress of Chemical Engineering and 6th European Congress of Applied Biotechnology, 20. - 23. September 2021, online
  • Siedentop R., Dziennus M., Lütz S., Rosenthal K. (selected for Poster Flash Talk)
    Identification of  Optimization Parameters in Cell-free Enzyme Cascades by Computer Modelling and Experimental Validation (Best poster award)
    5th Multistep Enzyme Catalyzed Pro­cess­es Conference (MECP2020+1), 13. - 16. September 2021, online
  • Rosenthal K., Becker M., Rolf J., Siedentop R., and Lütz S. (selected for Poster Pitch Talk)
    Single-step reaction and enzyme cascade – Biocatalytic synthesis routes for novel cyclic dinucleotides
    15th International Symposium on Biocatalysis and Biotransformations, 19.-22. July 2021, online
  • Rosenthal K., Rolf J., Becker M., Siedentop R., and Lütz S.
    Cell-free synthesis of enzymes for the production of pharmaceutically relevant molecules
    ProcessNet-Jahrestagung, 21. - 24. September 2020, online
  • Rosenthal K., Becker M., Rolf J, Nett M., and Lütz S. (2019)
    Enzymatic synthesis of cyclic dinucleotides – Exploring the catalytic potential of human cGAS (Best poster award)
    Trends in Enzymology and Biocatalysis, 27. - 31. May 2019, Rome, Italy

  • Rosenthal K., Battling S., Jünger M., Becker M., and Lütz S. (2018)
    Enzymatic synthesis of cyclic dinucleotides
    3nd Bioprocessing Days, 19. - 21. February 2018, Recklinghausen, Germany

  • Rosenthal K., Dusny C., and Schmid A. (2017)
    Single-cell physiological analysis
    2nd Bioprocessing Days, 20. - 22. February 2017, Recklinghausen, Germany

  • Rosenthal K., Dusny C., and Schmid A. (2016)
    Life of a single microbe in isolation
    ProcessNet-Jahrestagung, 12. - 15. September 2016, Aachen, Germany

  • Rosenthal K., Dusny C., Oehling V., Frick O. and Schmid A. (2014)
    Analysis of a single-cell: Imprisoned, but feeling well
    5th annual CLIB-graduate cluster retreat, 12. – 14. February 2014, Lünen, Germany

  • Dusny C., Fritzsch F. S. O., Rosenthal K. and Schmid A. (2014)
    Quantitative single cell analysis reveals faster growth of isolated microbes in controlled microenvironments in comparison to populations (Best poster award)
    SysBio2014 Advanced Lecture Course on Systems Biology, 02. – 08. March 2014, Innsbruck, Austria

  • Rosenthal K., Dusny C., Oehling V., Frick O. and Schmid A. (2014)
    The Envirostat 3.0: Microfluidic chip development for sampling of metabolites secreted by a single cell
    3rd BioProScale Symposium, 02. - 04. March 2014, Berlin, Germany

  • Rosenthal K., Fritzsch F. S. O., Dusny C., Oehling V., Frick O. and Schmid A. (2013)
    The Way for Single Cell Analysis: Pick the right, hold it tight, - then do a sight, if it’s bright
    4th annual CLIB-graduate cluster retreat, 13. – 15. February 2013, Lünen, Germany

  • Oehling V., Fritzsch F. S. O., Dusny C., Rosenthal K., Kortmann H., Frick O. and Schmid A. (2013)
    Single cell analysis of ethanol producing Saccharomyces cerevisiae
    3rd BE-Basic Symposium, 5. - 7. February 2013, Noordwijkerhout, The Netherlands

  • Dusny C., Fritzsch F. S. O., Rosenthal K., Frick O. and Schmid A. (2012)
    Quantitative physiology with isolated single cells and micropopulations in controlled microenvironments employing a picoliter bioreactor
    The 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS), 28. October – 1. November 2012, Okinawa, Japan

  • Rosenthal K., Fritzsch F. S. O., Dusny C., Oehling V., Frick O. and Schmid A. (2012)
    Fluoreszenz gestützte Analytik von Mikroorganismen im mikrofluidischen Einzelzellreaktor
    ProcessNet-Jahrestagung, 10. - 13. September 2012, Karlsruhe, Germany

  • Rosenthal K., Fritzsch F. S. O., Dusny C., Frick O., Blank L. M. and Schmid A. (2012)
    An Overview: Microbioreactors and Analytics for Systems biology on Single Cell Level
    2nd BioProScale Symposium, 14. - 16. March 2012, Berlin, Germany

  • Fritzsch F. S. O., Oehling V., Rosenthal K., Dusny C., Kampert A., Kortmann H., Frick O., Blank L. M. and Schmid A. (2012)
    Contactless single cell analysis of industrial relevant bacteria in controlled microenvironments
    2nd BioProScale Symposium, 14. - 16. March 2012, Berlin, Germany

  • Rosenthal K., Frick O. and Schmid A. (2012)
    Single cell analysis of industrial relevant microorganisms
    3rd annual CLIB-graduate cluster retreat, Bergisch-Gladbach, Germany

  • Dusny C., Fritzsch F. S. O., Rosenthal K., Parolina G., Frick O. and Schmid A. (2012)
    Beyond the bulk: Analysis and cultivation of single yeast and bacteria in precisely controlled extracellular environments (Best poster award)
    2nd BioProScale Symposium, 14. - 16. March 2012, Berlin, Germany

  • Rosenthal K., Fritzsch F. S. O., Dusny C., Frick O., Blank L. M. and Schmid A. (2011)
    Single Cell Analysis in Biotechnology A: An Overview: From defined Microenvironments towards Systems Biology
    Bubble Tech to Bio App – LAB-ON-A-CHIP, 17. - 18. October 2011, Saarbruecken, Germany

  • Fritzsch F. S. O., Rosenthal K., Dusny C., Kampert A., Kortmann H., Frick O., Blank L. M. and Schmid A. (2011)
    Single Cell Analysis in Biotechnology B: The Envirostat 2.0 – A next generation microfluidic platform for single cell analysis in controlled microenvironments
    Bubble Tech to Bio App – LAB-ON-A-CHIP, 17. - 18. October 2011, Saarbruecken, Germany

  • Dusny C., Fritzsch F. S. O., Rosenthal K., Parolina G., Oehling V., Frick O., Blank L. M. and Schmid A. (2011)
    Single Cell Analysis in Biotechnology C: Time-resolved quantitative physiology of trapped single yeast and bacteria in defined microenvironments
    Bubble Tech to Bio App – LAB-ON-A-CHIP, 17. - 18. October 2011, Saarbruecken, Germany